Description

3,5-Bis(Trifluoromethyl)Cyclohexanamine is a high-value, fluorinated amine building block characterized by its unique cyclohexane backbone substituted with two strongly electron-withdrawing trifluoromethyl groups. This structure is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules in advanced synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, particularly in the development of protease inhibitors, receptor antagonists, and other bioactive compounds where fluorine substitution is advantageous.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including potential treatments for central nervous system (CNS) disorders, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis, facilitating the production of enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and advanced organic frameworks (MOFs/COFs) with tailored electronic and surface properties.
• Fluorine Chemistry Building Block: Essential for introducing the CF3 moiety into complex molecular architectures in medicinal and process chemistry research programs.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Cyclohexanamine
CAS No.	58665-71-7
Molecular Formula	C8H9F6N
Molecular Weight	233.16 g/mol
Synonyms	3,5-Bis(trifluoromethyl)cyclohexanamine; 3,5-Bis(trifluoromethyl)cyclohexylamine; Cyclohexanamine, 3,5-bis(trifluoromethyl)-; 3,5-Di(trifluoromethyl)cyclohexanamine; 3,5-Bis(trifluoromethyl)-1-cyclohexanamine; 1-Amino-3,5-bis(trifluoromethyl)cyclohexane; 3,5-Bis(trifluoromethyl)cyclohexaneamine
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Cyclohexanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Isomer Ratio (cis/trans)	Reported on COA
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.