Description

2-(Trifluoromethyl)Cyclohexanamine is a versatile fluorinated amine building block, valued for its unique combination of a cyclohexyl backbone and a strongly electron-withdrawing trifluoromethyl group. This structure makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of advanced active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for developing novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the CF₃ group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Incorporated into specialty polymers and liquid crystals to modify thermal and chemical resistance properties.
• Organic Synthesis Building Block: Employed in medicinal chemistry for lead optimization and structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-(Trifluoromethyl)Cyclohexanamine
CAS No.	58665-69-3
Molecular Formula	C₇H₁₂F₃N
Molecular Weight	167.17 g/mol
Synonyms	2-(Trifluoromethyl)cyclohexanamine; 2-(Trifluoromethyl)cyclohexylamine; α-(Trifluoromethyl)cyclohexylamine; Cyclohexanamine, 2-(trifluoromethyl)-; 2-Cyclohexyl-2,2,2-trifluoroethylamine (tautomeric form); 2-(Trifluoromethyl)-1-cyclohexanamine; 2-CF3-Cyclohexylamine
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Cyclohexanamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets exacting customer specifications. Certificates of Analysis (COA) with detailed results are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong acids and oxidizing agents. Due to its fluoride/strong alkali reactivity profile, ensure containers are kept tightly sealed and stored separately from reactive compounds.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.