Description

(R)-Propranolol-o-β-D-Glucuronide Min. 95% is a high-purity, stereochemically defined metabolite of the β-blocker propranolol. This compound is of critical importance as a certified reference standard for analytical and bioanalytical applications, ensuring accurate quantification and method validation. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in drug metabolism and pharmacokinetic (DMPK) studies.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the calibration of analytical instruments (HPLC, LC-MS) in quantitative analysis.
• Metabolite Identification & Profiling: Essential for identifying and quantifying the (R)-enantiomer of propranolol glucuronide in biological matrices during ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Bioanalytical Method Development & Validation: Serves as a critical component in developing and validating robust, sensitive, and specific assays for clinical and preclinical samples.
• Pharmacokinetic & Toxicokinetic Research: Enables precise tracking of metabolite formation and elimination rates to understand the drug's behavior in the body.
• Impurity Characterization: Acts as a known impurity or degradation product reference for quality control of propranolol active pharmaceutical ingredient (API) and finished dosage forms.
• Enantioselective Metabolism Studies: Facilitates research into the stereospecific metabolic pathways of propranolol, which exhibits different pharmacological activities for its enantiomers.

Basic Information

Product Name	(R)-Propranolol-o-β-D-Glucuronide Min. 95%
CAS No.	58657-79-7
Molecular Formula	C22H29NO8
Molecular Weight	435.47 g/mol
Synonyms	(R)-Propranolol O-β-D-Glucuronide; (R)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol O-β-D-Glucopyranosiduronic Acid; Propranolol (R)-O-Glucuronide; (R)-Propranolol Glucuronide; (R)-Propranolol β-D-Glucuronide; 1-[(2R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]naphthalene β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our (R)-Propranolol-o-β-D-Glucuronide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing chromatographic purity, enantiomeric excess, and other critical parameters. We adhere to stringent quality management protocols suitable for research and reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 95.0%
Water Content (KF)	Contact for details
Residue on Ignition	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.