Description

Cefamandole Lithium is a second-generation cephalosporin antibiotic in its lithium salt form, offering enhanced stability and solubility for pharmaceutical manufacturing. This compound is critical for formulating sterile injectable antibiotic preparations, ensuring reliable therapeutic efficacy against a broad spectrum of bacterial infections. It is primarily required by pharmaceutical companies and research institutions engaged in the development and production of parenteral antibiotics. Cefamandole Lithium CAS NO 58648-57-0 is a key intermediate for ensuring the quality and consistency of finished pharmaceutical products.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of sterile injectable antibiotic solutions and powders.
• Research & Development of new antibacterial agents and combination therapies in pharmaceutical sciences.
• Reference Standard in quality control laboratories for analytical method development and validation (HPLC, MS).
• Veterinary Pharmaceuticals for the development of antibacterial treatments for livestock and companion animals.
• Manufacturing of Generic Drugs as a cost-effective, high-quality API for cephalosporin-based generics.
• Microbiological Studies for in-vitro evaluation of bacterial susceptibility and resistance patterns.

Basic Information

Product Name	Cefamandole Lithium
CAS No.	58648-57-0
Molecular Formula	C18H17LiN6O5S2
Molecular Weight	460.40 g/mol
Synonyms	Cefamandole Lithium Salt; Mandol Lithium Salt; (6R,7R)-7-[[(2R)-2-Hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Lithium; Cefamandole Li; Lithium Cefamandolate; Cefamandole Lithium (USP); Cefamandole Lithium (EP)
EINECS	Contact for details

Quality Control

Our Cefamandole Lithium is manufactured under strict quality systems to meet the rigorous standards of the pharmaceutical industry. Each batch is tested to ensure compliance with relevant pharmacopeial specifications such as USP and EP. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing parameters including assay, purity, related substances, and residual solvents. Our commitment to GMP principles and analytical traceability guarantees a reliable and consistent API for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
pH (1% Solution)	5.0 - 7.0
Specific Rotation	+60° to +70° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.