Description

3-Maleimidobenzoic Acid N-Hydroxysuccinimide Ester is a high-purity, heterobifunctional crosslinking agent designed for advanced bioconjugation. This compound matters because it enables the precise and stable attachment of biomolecules, such as proteins and peptides, to surfaces or other molecules via its amine-reactive NHS ester and thiol-reactive maleimide groups. It is essential for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science who require reliable, site-specific conjugation for creating stable, functional constructs.

Application

• Antibody-Drug Conjugate (ADC) Linker: A critical component for constructing stable, cleavable, or non-cleavable linkers between cytotoxic drugs and monoclonal antibodies.
• Protein and Peptide Labeling: For site-specific fluorescent, enzymatic, or affinity tag conjugation to proteins via free cysteine residues and amine groups.
• Surface Functionalization: Immobilization of biomolecules onto chips, beads, or biosensor surfaces for diagnostic and research applications.
• Polymer Modification: Synthesis of functionalized polymers and hydrogels for drug delivery systems and tissue engineering scaffolds.
• Diagnostic Reagent Development: Production of enzyme conjugates and labeled antigens/antibodies for ELISA, lateral flow assays, and other immunoassays.
• Biomaterial Crosslinking: Creating crosslinked networks in biomaterials to control mechanical properties and degradation profiles.

Basic Information

Product Name	3-Maleimidobenzoic Acid N-Hydroxysuccinimide Ester
CAS No.	58626-38-3
Molecular Formula	C15H10N2O6
Molecular Weight	314.25 g/mol
Synonyms	3-Maleimidobenzoic Acid NHS Ester; 3-Maleimidobenzoic Acid N-Succinimidyl Ester; 3-Maleimidobenzoyl N-Hydroxysuccinimide Ester; MB-NHS; 3-MBA-NHS; 3-Maleimidobenzoyl NHS Ester; N-(3-Maleimidobenzoyloxy)succinimide; 3-Maleimidobenzoic Acid, N-Hydroxysuccinimide Ester
EINECS	Contact for details

Quality Control

Our 3-Maleimidobenzoic Acid N-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	95.0% - 105.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.