Description

Dimethyl Pimelimidate Dihydrochloride is a homobifunctional, amine-reactive crosslinking agent widely used in biochemical research and bioconjugation. Its primary value lies in its ability to create stable covalent bonds between primary amines under mild aqueous conditions, forming amidine linkages. This compound is essential for researchers and manufacturers in the fields of protein chemistry, antibody-drug conjugate (ADC) development, and biomaterial fabrication, where precise molecular conjugation is critical.

Application

• Protein Crosslinking and Immobilization: Used to crosslink proteins, enzymes, or antibodies to solid supports (e.g., agarose beads, magnetic particles) for affinity chromatography, diagnostics, and biosensor development.
• Antibody Modification: A key reagent for modifying monoclonal antibodies with drugs, toxins, or fluorescent probes in the development of targeted therapeutics and diagnostic imaging agents.
• Cell Surface Labeling: Employed to label cell surface proteins and receptors for flow cytometry, microscopy, and studying cell-cell interactions.
• Nucleic Acid Conjugation: Facilitates the conjugation of oligonucleotides to proteins or other carriers for gene delivery and molecular biology applications.
• Vaccine Development: Used as a coupling agent to conjugate haptens to carrier proteins, enhancing immunogenicity in vaccine formulation research.
• Polymer and Biomaterial Synthesis: Serves as a crosslinker in the synthesis of hydrogels, polymer networks, and other biomaterials with tailored mechanical and biological properties.

Basic Information

Product Name	Dimethyl Pimelimidate Dihydrochloride
CAS No.	58537-94-3
Molecular Formula	C9H18N2O2 • 2HCl
Molecular Weight	283.17 g/mol
Synonyms	Pimelimidic Acid Dimethyl Ester Dihydrochloride; DMP • 2HCl; Dimethyl Pimelimidate Dihydrochloride; Dimethyl Heptanedimidate Dihydrochloride; Heptanedimidic Acid, Dimethyl Ester, Dihydrochloride; 1,7-Dimethyl Pimelimidate Dihydrochloride; NSC 112204; BDBM50403225
EINECS	Contact for details

Quality Control

Our Dimethyl Pimelimidate Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for sensitive research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Clear, colorless solution in water or buffer
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.