Description

Estrone 3-Hemisuccinate is a chemically modified derivative of the natural estrogen, estrone, designed to enhance solubility and stability for advanced pharmaceutical applications. This high-purity intermediate is critical for the synthesis of conjugated estrogens and other steroidal active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical producers engaged in hormone therapy development and steroidal synthesis.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of conjugated estrogens and other steroidal APIs for hormone replacement therapy (HRT).
• Biochemical Research: Used as a reference standard or reagent in endocrinology and metabolic pathway studies.
• Steroid Prodrug Development: The hemisuccinate ester group facilitates the creation of prodrugs with improved bioavailability and pharmacokinetic profiles.
• Veterinary Medicine: Component in the development of hormonal treatments for animals.
• Diagnostic Reagents: Potential use in the manufacture of reagents for clinical diagnostic assays measuring estrogen levels.

Basic Information

Product Name	Estrone 3-Hemisuccinate
CAS No.	58534-72-8
Molecular Formula	C23H30O6
Molecular Weight	402.48 g/mol
Synonyms	Estrone 3-hemisuccinate; Estrone 3-hemisuccinate ester; Estrone 3-(succinyl ester); 3-Hemisuccinoyloxyestra-1,3,5(10)-trien-17-one; Oestra-1,3,5(10)-trien-17-one, 3-(3-carboxypropionyloxy)-; Estrone hemisuccinate; NSC 135023
EINECS	Contact for details

Quality Control

Our Estrone 3-Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical R&D and synthesis. A detailed Certificate of Analysis (COA) documenting purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.