Description

Thiothixene Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial importance. Its primary value lies in its role as the active component in the production of antipsychotic medications, where consistent quality and purity are paramount for therapeutic efficacy and safety. This compound is essential for manufacturers in the pharmaceutical industry, particularly those specializing in central nervous system (CNS) drugs and generic formulations.

Application

• Pharmaceutical API Manufacturing: Primary use as the active ingredient in the formulation of antipsychotic medications.
• Generic Drug Production: Serves as a critical raw material for the synthesis of generic versions of branded neuroleptic drugs.
• Research & Development (R&D): Used in pharmacological studies and the development of new CNS-targeting therapeutic agents.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method validation and testing.
• Clinical Trial Material: Supplied as a GMP-grade intermediate for the production of drugs used in clinical research phases.

Basic Information

Product Name	Thiothixene Hydrochloride
CAS No.	58513-59-0
Molecular Formula	C23H29N3O2S2·HCl
Molecular Weight	492.08 g/mol
Synonyms	Thiothixene HCl; Tiotixene Hydrochloride; Navane (brand name); N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide Hydrochloride; 9-[3-(Dimethylamino)propylidene]-2-(methylsulfonyl)thioxanthene Hydrochloride; CP-12252-1; P-4657B
EINECS	Contact for details

Quality Control

Our Thiothixene Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided with every shipment, detailing results from tests such as HPLC assay, related substances, residual solvents, and heavy metals. We support compliance with major pharmacopoeial standards (e.g., USP, EP) and can supply material suitable for GMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.