Description

Diflunisal Glucuronide Ester is a key metabolite and reference standard of the non-steroidal anti-inflammatory drug (NSAID) diflunisal. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery and regulatory compliance activities.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of diflunisal metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance, and bioavailability of diflunisal.
• Bioanalytical Method Development: Critical for developing and validating HPLC, LC-MS, or GC-MS assays for therapeutic drug monitoring and preclinical studies.
• Impurity Profiling: Employed as a known impurity or degradation product standard to ensure drug substance and product purity per ICH guidelines.
• Toxicological Research: Aids in understanding the safety profile and potential toxic metabolites associated with diflunisal therapy.

Basic Information

Product Name	Diflunisal Glucuronide Ester
CAS No.	58446-30-3
Molecular Formula	C21H20F2O9
Molecular Weight	454.38 g/mol
Synonyms	Diflunisal 1-O-Acyl Glucuronide; Diflunisal Acyl Glucuronide; 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid β-D-glucopyranosiduronic acid ester; 5-(2,4-Difluorophenyl)-2-hydroxybenzoic acid 1-(β-D-glucopyranuronosyl) ester; Diflunisal O-Glucuronide
EINECS	Contact for details

Quality Control

Our Diflunisal Glucuronide Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (NMR, IR, MS) and purity assessment by HPLC to ensure it meets the high standards required for research and reference material applications. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content	≤ 5.0%
Residual Solvents	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.