Description

Diflunisal Glucuronide Ether is a key metabolite and reference standard of the non-steroidal anti-inflammatory drug (NSAID) Diflunisal. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery and regulatory compliance activities.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of Diflunisal metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, clearance rates, and bioavailability of Diflunisal.
• Bioanalytical Method Development: Used to validate High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS/MS) assays for clinical and preclinical studies.
• Impurity Profiling: Employed as a known impurity or degradation product to ensure the purity and stability of Diflunisal drug substances and products.
• Toxicological Research: Aids in understanding the safety profile and potential side effects associated with Diflunisal therapy.

Basic Information

Product Name	Diflunisal Glucuronide Ether
CAS No.	58446-29-0
Molecular Formula	C21H20F2O9
Molecular Weight	454.38 g/mol
Synonyms	Diflunisal 1-O-Acyl Glucuronide; Diflunisal Acyl Glucuronide; 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid 1-β-O-acyl glucuronide; 1-O-(2',4'-Difluoro-4-hydroxy[1,1'-biphenyl]-3-carbonyl)-β-D-glucopyranuronic acid; Diflunisal β-1-O-Acyl Glucuronide; DIFLUNISAL GLUCURONIDE
EINECS	Contact for details

Quality Control

Our Diflunisal Glucuronide Ether is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical reference materials. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.