Description

Z-Asp(Onp)-Obzl is a protected aspartic acid derivative, specifically the benzyl ester of aspartic acid with an o-nitrophenyl (Onp) protecting group on the side chain carboxyl. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, reliable intermediates for developing therapeutic peptides, peptide hormones, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the controlled incorporation of aspartic acid into peptide chains.
• Pharmaceutical Intermediate: Used in the research and development of therapeutic peptides targeting metabolic disorders, cancer, and cardiovascular diseases.
• Biochemical Research: Serves as a crucial reagent for studying enzyme-substrate interactions, protein folding, and peptide structure-activity relationships (SAR).
• Custom Peptide Production: Employed by CROs and CDMOs for the synthesis of custom peptides for clinical trials and diagnostic applications.
• Protecting Group Chemistry: The o-nitrophenyl (Onp) group allows for selective deprotection under mild conditions, facilitating complex synthetic strategies.

Basic Information

Product Name	Z-Asp(Onp)-Obzl
CAS No.	58238-28-1
Molecular Formula	C25H22N2O8
Molecular Weight	478.45 g/mol
Synonyms	N-Carbobenzoxy-L-aspartic acid 4-benzyl ester 1-(2-nitrophenyl) ester; Z-L-Aspartic acid α-benzyl ester β-(2-nitrophenyl) ester; Z-Asp(ONp)-OBzl; Nα-Benzyloxycarbonyl-L-aspartic acid β-(2-nitrophenyl) ester α-benzyl ester; Benzyl N-[(benzyloxy)carbonyl]-L-β-aspartate 4-(2-nitrophenyl) ester; Z-Asp-OBzl(ONp); CBZ-Asp(ONp)-OBzl
EINECS	Contact for details

Quality Control

Our Z-Asp(Onp)-Obzl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation [α]	Specification available upon request
Melting Point	Specification available upon request
Heavy Metals	<10 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.