Description

(6R-Trans)-3-(Acetoxymethyl)-7-[(2-Aminothiazol-4-Yl)Acetamido]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a key advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of third-generation cephalosporin antibiotics, offering a high-purity building block for complex pharmaceutical manufacturing. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical suppliers engaged in the production of advanced β-lactam antibiotics.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate in the chemical synthesis of third-generation cephalosporin antibiotics such as cefotaxime.
• Pharmaceutical Research & Development: Used as a critical starting material or intermediate in the discovery and process development of new β-lactam antibacterial agents.
• Fine Chemical Manufacturing: Serves as a high-value building block for custom synthesis and contract manufacturing organizations (CMOs) specializing in complex molecules.
• Reference Standard Production: Utilized in the preparation of analytical reference standards and impurities for quality control and regulatory compliance testing in the pharmaceutical industry.

Basic Information

Product Name	(6R-Trans)-3-(Acetoxymethyl)-7-[(2-Aminothiazol-4-Yl)Acetamido]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	58233-18-4
Molecular Formula	C16H16N4O6S2
Molecular Weight	424.45 g/mol
Synonyms	7-ACA Derivative (Aminothiazolyl); 7-[(2-Aminothiazol-4-yl)acetamido]cephalosporanic Acid Derivative; Cefotaxime Intermediate; 7-ATACA; (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (related); 3-Acetoxymethyl-7-(2-aminothiazol-4-yl)acetamido-3-cephem-4-carboxylic Acid; 7-ACA-AT; 7-ADCA Derivative
EINECS	Contact for details

Quality Control

Our (6R-Trans)-3-(Acetoxymethyl)-7-[(2-Aminothiazol-4-Yl)Acetamido]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under controlled humidity conditions. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.