Description

(E)-3-[3-(Trifluoromethyl)Phenyl]Acrylonitrile is a high-purity, versatile chemical intermediate featuring a trifluoromethyl-substituted aromatic ring conjugated to an acrylonitrile moiety. This compound matters for its role as a critical building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this valuable fluorinated motif into novel molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display and lighting technologies, improving charge transport and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance thermal stability, chemical resistance, and optical properties.
• Cross-Coupling Reactions: Acts as an excellent substrate in Heck, Suzuki, and other palladium-catalyzed cross-coupling reactions for constructing complex organic architectures.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	(E)-3-[3-(Trifluoromethyl)Phenyl]Acrylonitrile
CAS No.	58177-64-3
Molecular Formula	C10H6F3N
Molecular Weight	197.16 g/mol
Synonyms	(E)-3-[3-(Trifluoromethyl)phenyl]-2-propenenitrile; 3-(3-Trifluoromethylphenyl)acrylonitrile; trans-3-(3-Trifluoromethylphenyl)acrylonitrile; (E)-3-(3-Trifluoromethylphenyl)acrylonitrile; 3-(α,α,α-Trifluoro-m-tolyl)acrylonitrile; (E)-3-(3-(Trifluoromethyl)phenyl)acrylonitrile; m-Trifluoromethylcinnamonitrile; 2-Propenenitrile, 3-[3-(trifluoromethyl)phenyl]-, (E)-
EINECS	Contact for details

Quality Control

Our (E)-3-[3-(Trifluoromethyl)Phenyl]Acrylonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isomeric Purity (E-isomer)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.