Description

Hemoglobin J is a specific variant of hemoglobin, the essential oxygen-transporting metalloprotein found in red blood cells. This high-purity biochemical is critical for advanced research and diagnostic applications where precise molecular characterization is required. It serves as a vital reference standard and raw material for researchers and manufacturers in the life sciences, pharmaceutical development, and clinical diagnostics sectors.

Application

• Biochemical Research: Used as a purified protein standard in studies of hemoglobin structure, function, and oxygen-binding kinetics.
• Diagnostic Reagent Manufacturing: Serves as a key component in the production of calibrators and controls for hematology analyzers and clinical chemistry assays.
• Pharmaceutical Development: Employed in preclinical research for investigating blood substitute technologies and oxygen-carrier therapeutics.
• Reference Material: Acts as an analytical standard for method validation in laboratories performing hemoglobin variant analysis (e.g., HPLC, electrophoresis).
• Enzyme & Cell Culture Supplements: May be utilized in specialized cell culture media and enzymatic reaction systems requiring heme-based cofactors.
• Educational & Training Kits: Incorporated into educational kits for teaching advanced concepts in protein chemistry and human physiology.

Basic Information

Product Name	Hemoglobin J
CAS No.	58128-48-6
Molecular Formula	C2952H4664N812O832S40Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb J; Hemoglobin variant J; Deoxyhemoglobin J; Oxyhemoglobin J; Methemoglobin J; Human Hemoglobin J; α-2-Globin variant; β-Globin variant; Hemoglobin alpha chain variant
EINECS	Contact for details

Quality Control

Our Hemoglobin J is produced and handled under stringent quality management protocols. Each batch is subjected to comprehensive analytical testing to ensure identity, purity, and biological activity. A detailed Certificate of Analysis (COA) is provided, which includes data from relevant methods such as HPLC purity, electrophoresis, spectrophotometric analysis, and endotoxin testing where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture. For extended storage, consider aliquoting and freezing at -20°C or below under inert atmosphere.

Specification

Item	Specification
Appearance	Dark red to brown lyophilized powder or solution
Identification (IR / UV-Vis)	Conforms to standard
Purity (HPLC)	≥ 95% (Hemoglobin J)
Protein Content (Biuret)	≥ 90%
Methemoglobin Content	≤ 5%
Solubility	Clear solution in buffer
pH (in solution)	6.5 - 7.5
Endotoxin (where specified)	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.