Description

Fmoc-Arg(No2)-Oh is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound, with CAS No. 58111-94-7, serves as a critical building block for the controlled introduction of nitroarginine into peptide chains, enabling advanced research into protein structure and function. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in the development of novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated, stepwise construction of custom peptide sequences.
• Nitric Oxide Synthase (NOS) Research: For synthesizing peptide substrates and inhibitors to study enzyme kinetics and regulation.
• Bioconjugation & Probe Development: Enables the site-specific incorporation of a nitroarginine moiety into larger biomolecules for labeling and interaction studies.
• Pharmaceutical Intermediate: Serves as a key raw material in the research and development stages of peptide-based drug candidates.
• Biochemical Tool Compound Production: Used to create specialized peptides for cell signaling pathway analysis and diagnostic assay development.

Basic Information

Product Name	Fmoc-Arg(No2)-Oh
CAS No.	58111-94-7
Molecular Formula	C₂₂H₂₅N₅O₆
Molecular Weight	455.47 g/mol
Synonyms	Fmoc-NG-Nitro-L-arginine; Nα-Fmoc-NG-nitro-L-arginine; Fmoc-L-Arg(NO₂)-OH; (2S)-5-[(Amino-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}methylidene)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-nitro-pentanoic acid; Fmoc-Nitroarginine; Nα-(9-Fluorenylmethyloxycarbonyl)-NG-nitro-L-arginine; Fmoc-Arg(NO₂)-OH; Fmoc-Nω-Nitro-L-arginine
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(No2)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.