Description

Ethyl 2,4-Difluorobenzoylacetate is a high-purity fluorinated organic building block essential for advanced chemical synthesis. This compound is valued for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought by R&D chemists and process development teams for constructing active pharmaceutical ingredients (APIs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, including kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the difluorobenzoyl moiety imparts desired biological activity and stability.
• Material Science Research: Serves as a building block for creating novel fluorinated polymers and liquid crystals with unique properties.
• Organic Synthesis: Employed in various name reactions, such as Claisen condensations and Michael additions, to construct complex β-ketoester frameworks.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Ethyl 2,4-Difluorobenzoylacetate
CAS No.	58101-23-8
Molecular Formula	C11H10F2O3
Molecular Weight	228.19 g/mol
Synonyms	Ethyl (2,4-Difluorobenzoyl)acetate; Acetic acid, 2-(2,4-difluorobenzoyl)-, ethyl ester; 2,4-Difluorobenzoylacetic Acid Ethyl Ester; Ethyl 2-(2,4-Difluorobenzoyl)acetate; 3-Oxo-3-(2,4-difluorophenyl)propanoic acid ethyl ester; 58101-23-8; Ethyl 2,4-difluoro-β-oxobenzene propanoate
EINECS	Contact for details

Quality Control

Our Ethyl 2,4-Difluorobenzoylacetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.