Description

(6R-Trans)-7-Amino-8-Oxo-3-[(1H-Tetrazol-5-Ylthio)Methyl]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of next-generation β-lactam antibiotics, offering a key structural scaffold for developing potent antimicrobial agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of novel cephalosporin-based drugs to combat resistant bacterial infections.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core intermediate in the chemical synthesis of advanced cephalosporin antibiotics.
• Antimicrobial Research & Development: Used as a key building block in medicinal chemistry for designing and testing new antibacterial compounds with improved efficacy.
• Pharmaceutical Process Development: Employed in scaling up and optimizing manufacturing processes for cephalosporin drugs in GMP facilities.
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory testing of finished pharmaceutical products.
• Bioconjugation Studies: Utilized in research exploring targeted drug delivery systems due to its reactive functional groups.

Basic Information

Product Name	(6R-Trans)-7-Amino-8-Oxo-3-[(1H-Tetrazol-5-Ylthio)Methyl]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	58016-87-8
Molecular Formula	C10H11N7O3S2
Molecular Weight	341.37 g/mol
Synonyms	7-ACA Tetrazolyl Thioether Derivative; 7-Aminocephalosporanic Acid Tetrazole Thioether; 3-[(1H-Tetrazol-5-ylthio)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-Amino-3-[(1H-tetrazol-5-ylsulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cephalosporin C Nucleus Tetrazole; 7-ACA-TT; 58016-87-8
EINECS	Contact for details

Quality Control

Our (6R-Trans)-7-Amino-8-Oxo-3-[(1H-Tetrazol-5-Ylthio)Methyl]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.