Description

n-(Trifluoroacetyl)-L-Norvaline 1-Methylpropyl Ester is a specialized chiral building block and protected amino acid derivative. This compound is valued for its role in advanced organic synthesis, particularly in the preparation of peptides and peptidomimetics where the trifluoroacetyl group serves as a versatile protecting group. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs) and therapeutic peptides.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected L-norvaline derivative, facilitating specific coupling reactions.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the creation of compound libraries for drug discovery screening.
• Bioconjugation: Serves as a precursor for modifying biomolecules, useful in probe and linker development for biochemical assays.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to induce chirality in target molecules.
• Process Chemistry: Investigated for scalable routes in the production of complex organic molecules requiring the L-norvaline moiety.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Norvaline 1-Methylpropyl Ester
CAS No.	57983-22-9
Molecular Formula	C11H18F3NO3
Molecular Weight	269.26 g/mol
Synonyms	L-Norvaline, N-(trifluoroacetyl)-, 1-methylpropyl ester; N-(Trifluoroacetyl)-L-norvaline sec-butyl ester; (S)-2-((2,2,2-Trifluoroacetamido)pentanoic acid 1-methylpropyl ester; 2-(2,2,2-Trifluoroacetamido)pentanoic acid sec-butyl ester; N-[(2,2,2-Trifluoroacetyl)-L-norvaline sec-butyl ester; sec-Butyl N-(trifluoroacetyl)-L-norvalinate; 57983-22-9; N-TFA-L-norvaline sec-butyl ester
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Norvaline 1-Methylpropyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and specific rotation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Optical Rotation [α]	Contact for details
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.