Description

Vitamin D3 β-D-Glucuronide is a crucial conjugated metabolite of Vitamin D3, formed by the enzymatic attachment of glucuronic acid, which significantly enhances its water solubility and alters its biological activity and excretion profile. This compound is of paramount importance in advanced biochemical research and pharmaceutical development, particularly for studying Vitamin D metabolism, transport, and detoxification pathways. It serves as a vital reference standard and intermediate for manufacturers and research institutions focused on endocrinology, nutraceuticals, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Critical for the qualitative and quantitative analysis (HPLC, LC-MS) of Vitamin D metabolites in drug development and clinical research.
• Biochemical Research: Used to study the Phase II metabolism, transport mechanisms (e.g., via MRP transporters), and renal/biliary excretion of Vitamin D3 and its analogs.
• Nutraceutical & Dietary Supplement Research: Investigated for its potential bioavailability, stability, and biological effects compared to non-conjugated forms of Vitamin D.
• Diagnostic Kit Development: Employed as a key calibrant or component in the development of immunoassays and kits for measuring Vitamin D status and metabolic profiles.
• Metabolite Synthesis: Acts as a sophisticated synthetic intermediate for preparing other labeled or modified Vitamin D metabolites for tracer studies.

Basic Information

Product Name	Vitamin D3 β-D-Glucuronide
CAS No.	57918-08-8
Molecular Formula	C33H52O8
Molecular Weight	576.76 g/mol
Synonyms	Cholecalciferol 3β-D-Glucuronide; Vitamin D3 Glucuronide; Cholecalciferol Glucuronide; (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-yl β-D-Glucopyranosiduronic Acid; Colecalciferol Glucuronide; 3β-Hydroxycholecalciferol β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Vitamin D3 β-D-Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. The product is hygroscopic (moisture-sensitive) and should be kept under inert atmosphere or desiccated after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.