Description

1'-Hydroxybufuralol is a key metabolite of bufuralol, a compound of significant interest in pharmacological and biochemical research. Its primary value lies in its role as a reference standard for studying cytochrome P450 2D6 (CYP2D6) enzyme activity, which is critical for drug metabolism and pharmacogenetics. This makes it an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug development, metabolic pathway analysis, and enzyme inhibition studies.

Application

• Pharmacological Research: Used as a critical metabolite standard in studies investigating the pharmacokinetics and metabolic pathways of bufuralol and related β-blockers.
• Enzyme Activity Assays: Serves as a specific substrate and reference compound for measuring the activity of the CYP2D6 isoenzyme, a major enzyme in drug metabolism.
• Drug Development & Safety Testing: Employed in in vitro studies to assess drug-drug interaction potential and to characterize the metabolic profile of new chemical entities.
• Biomarker and Diagnostic Tool Development: Utilized in the development of analytical methods for phenotyping CYP2D6 activity, which is relevant for personalized medicine.
• Quality Control & Method Validation: Acts as a certified reference material (CRM) for the calibration and validation of HPLC, LC-MS, and other analytical instruments in bioanalytical laboratories.
• Academic Research: Used in university and institutional research projects focused on enzymology, toxicology, and molecular pharmacology.

Basic Information

Product Name	1'-Hydroxybufuralol
CAS No.	57704-16-2
Molecular Formula	C16H23NO3
Molecular Weight	277.36 g/mol
Synonyms	1'-Hydroxybufuralol; 1-Hydroxybufuralol; 1'-OH-Bufuralol; Bufuralol 1'-hydroxylate; (RS)-1'‑Hydroxybufuralol; 2-(tert-Butylamino)-1-(7-ethyl-1-hydroxy-1,2,3,4-tetrahydro-2-naphthyl)ethanol; Bufuralol metabolite
EINECS	Contact for details

Quality Control

Our 1'-Hydroxybufuralol is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We support compliance with relevant Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.