Description

n-α-Trityl-L-Asparagine is a protected derivative of the amino acid L-asparagine, where the α-amino group is shielded by a trityl (triphenylmethyl) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, bioactive compounds, and novel materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the sequential construction of peptide chains, particularly where orthogonal protection strategies are required.
• Pharmaceutical Intermediate: Serves as a crucial intermediate in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Used in academic and industrial laboratories for studying protein structure-function relationships, enzyme substrates, and signal transduction pathways.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Protecting Group Chemistry: The trityl group offers selective protection and deprotection capabilities, useful in complex multi-step organic syntheses.

Basic Information

Product Name	n-α-Trityl-L-Asparagine
CAS No.	57618-17-4
Molecular Formula	C25H24N2O3
Molecular Weight	400.47 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-asparagine; Fmoc-L-Asn-OH; Fmoc-Asparagine; N-α-Fmoc-L-asparagine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]butanediamide; Fmoc-Asn-OH; N-(9-Fluorenylmethoxycarbonyl)-L-asparagine; L-Asparagine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our n-α-Trityl-L-Asparagine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.