Description

n-Trifluoroacetyl (R)-Amphetamine is a chiral, fluorinated derivative of amphetamine, serving as a key synthetic intermediate and reference standard. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and for analytical method development. It is primarily needed by research institutions, pharmaceutical companies, and analytical laboratories engaged in neuropharmacology, medicinal chemistry, and forensic science.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of fluorinated amphetamine analogs and other central nervous system (CNS) targeted compounds.
• Reference Standard: Used for qualitative and quantitative analysis in high-performance liquid chromatography (HPLC), gas chromatography (GC), and mass spectrometry (MS) for method validation and calibration.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to investigate the impact of fluorination and chirality on biological activity and metabolic stability.
• Metabolite Standard: Serves as a reference compound for the identification and quantification of potential metabolites in pharmacokinetic and toxicological studies.
• Forensic Analysis: Utilized as an analytical standard in forensic laboratories for the precise identification of related substances in compliance and law enforcement testing.

Basic Information

Product Name	n-Trifluoroacetyl (R)-Amphetamine
CAS No.	57573-45-2
Molecular Formula	C₁₁H₁₂F₃NO
Molecular Weight	231.21 g/mol
Synonyms	(R)-1-Phenyl-2-(trifluoroacetamido)propane; (R)-N-(1-Phenylpropan-2-yl)-2,2,2-trifluoroacetamide; (R)-N-Trifluoroacetylamphetamine; (R)-Amphetamine trifluoroacetamide; (R)-TFAA-amphetamine; (R)-N-TFA-amphetamine; (R)-α-Methylphenethylamine trifluoroacetamide
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetyl (R)-Amphetamine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R)-enantiomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.