Description

4-Bromo-3-Chlorobenzonitrile is a versatile halogenated benzonitrile derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in providing a reactive aromatic scaffold with multiple orthogonal functional handles for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, where it is used to develop active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing functionalized aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the presence of both bromo and chloro substituents.
• Organic Synthesis & Research: A valuable reagent in academic and industrial R&D labs for exploring novel heterocyclic compounds and complex organic transformations.
• Polymer Modification: Used to introduce cyano and halogen functional groups into polymer backbones, altering material properties like thermal stability and solubility.

Basic Information

Product Name	4-Bromo-3-Chlorobenzonitrile
CAS No.	57418-97-0
Molecular Formula	C7H3BrClN
Molecular Weight	216.46 g/mol
Synonyms	3-Chloro-4-bromobenzonitrile; 4-Bromo-3-chlorobenzene carbonitrile; 1-Bromo-2-chloro-4-cyanobenzene; Benzonitrile, 4-bromo-3-chloro-; 2-Chloro-4-cyanobromobenzene; 4-Cyano-2-chlorobromobenzene; (4-Bromo-3-chlorophenyl)carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Chlorobenzonitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP and ISO principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 99 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.