Description

5,6-Dihydro-5-Azathymidine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a key intermediate and building block in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases and cellular DNA replication pathways. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics. The high-purity material is essential for ensuring the efficacy and safety profile of the final active pharmaceutical ingredients.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of experimental antiviral and antineoplastic drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to thymidine metabolism and DNA synthesis.
• Antiviral Drug Development: Serves as a precursor in the creation of nucleoside analogs targeting viruses such as herpesviruses and hepatitis B.
• Oncology Research: Investigated for its potential incorporation into DNA chain-terminating agents for cancer therapy.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex nucleoside derivatives.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	5,6-Dihydro-5-Azathymidine
CAS No.	57350-36-4
Molecular Formula	C9H13N3O5
Molecular Weight	243.22 g/mol
Synonyms	5,6-Dihydro-5-azathymidine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5,6-dihydro-5-azathymine; 5-Aza-5,6-dihydrothymidine; 5,6-Dihydro-5-aza-2'-deoxythymidine; NSC 154020; Dihydro-5-azathymidine; 5-Azadihydrothymidine
EINECS	Contact for details

Quality Control

Our 5,6-Dihydro-5-Azathymidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of the pharmaceutical industry. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.