Description

[(20S)-5α-Pregnane-3α,11β,20,21-Tetryl]Tetra(Oxy)]Tetrakis(Trimethylsilane) is a high-purity, organosilicon-protected steroid derivative, specifically designed for advanced synthetic chemistry and pharmaceutical research. This compound serves as a critical protected intermediate, enabling precise chemical transformations while safeguarding sensitive functional groups. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for the synthesis of complex steroid-based molecules and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of corticosteroid analogs and other bioactive steroid molecules.
• Process Chemistry: Used in the development and scale-up of manufacturing routes for active pharmaceutical ingredients (APIs) requiring selective protection/deprotection strategies.
• Medicinal Chemistry Research: Enables the exploration of new chemical entities (NCEs) by providing a versatile, protected scaffold for structure-activity relationship (SAR) studies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in steroid analysis.
• Biochemical Probes: Potential use in the development of labeled compounds or probes for studying steroid hormone pathways and receptor interactions.

Basic Information

Product Name	[(20S)-5α-Pregnane-3α,11β,20,21-Tetryl]Tetra(Oxy)]Tetrakis(Trimethylsilane)
CAS No.	57326-10-0
Molecular Formula	C40H84O4Si4
Molecular Weight	741.48 g/mol
Synonyms	5α-Pregnane-3α,11β,20,21-tetrol, 3,11,20,21-tetrakis(trimethylsilyl) ether, (20S)-; Tetrakis-O-(trimethylsilyl)tetrahydrocortisol; 3α,11β,20,21-Tetrakis(trimethylsiloxy)-5α-pregnane; 5α-Pregnane-3α,11β,20,21-tetrol tetra(trimethylsilyl) ether; 3,11,20,21-Tetrakis-O-trimethylsilyl-5α-tetrahydrocortisol; Protected Tetrahydrocortisol; TMS-derivative of 5α-Tetrahydrocortisol.
EINECS	Contact for details

Quality Control

Our [(20S)-5α-Pregnane-3α,11β,20,21-Tetryl]Tetra(Oxy)]Tetrakis(Trimethylsilane) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.