Description

Carbobenzyloxyglycyl-L-Proline Benzyl Ester is a protected dipeptide building block widely used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise stereochemistry. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of therapeutic peptides and peptidomimetics.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected Gly-Pro dipeptide unit for the sequential assembly of longer peptide chains on resin.
• Biochemical Research: Employed in studies of enzyme substrates, inhibitors, and receptor ligands where the Gly-Pro sequence is relevant.
• Protease Inhibitor Development: Serves as a core structure or intermediate in the design of inhibitors targeting proline-specific enzymes.
• Combinatorial Chemistry: A valuable reagent in libraries for drug discovery and structure-activity relationship (SAR) studies.
• Custom Peptide Service: A standard reagent used by CROs and CDMOs for the contract manufacturing of custom peptide sequences.

Basic Information

Product Name	Carbobenzyloxyglycyl-L-Proline Benzyl Ester
CAS No.	57294-41-4
Molecular Formula	C22H24N2O5
Molecular Weight	396.44 g/mol
Synonyms	Z-Gly-Pro-OBzl; Cbz-Gly-L-Pro-OBzl; Benzyl N-[(benzyloxy)carbonyl]glycyl-L-prolinate; N-Carbobenzyloxyglycyl-L-proline Benzyl Ester; Z-Gly-Pro-OBz; CBZ-Gly-Pro-OBzl; Z-Gly-Pro-OBz; (S)-Benzyl 2-((((benzyloxy)carbonyl)amino)acetyl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our Carbobenzyloxyglycyl-L-Proline Benzyl Ester is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.