Description

Boc-D-4-Chlorophe CAS NO 57292-44-1 is a protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) derivative of D-4-chlorophenylalanine. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, valued for its role in introducing the D-isomer of 4-chlorophenylalanine into target molecules. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive compounds where stereochemical control and specific side-chain functionality are essential.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-4-chlorophenylalanine residue, which can enhance metabolic stability and modulate biological activity.
• Protease Inhibitor Development: Serves as a building block for creating inhibitors targeting specific proteases, relevant in antiviral, anticancer, and anti-inflammatory research.
• Biochemical Research: Employed in academic and industrial laboratories for studying enzyme-substrate interactions, structure-activity relationships (SAR), and protein engineering.
• Production of Non-Natural Amino Acids: Acts as a precursor for further chemical modifications to create specialized, non-proteinogenic amino acid analogs.

Basic Information

Product Name	Boc-D-4-Chlorophe CAS NO 57292-44-1
CAS No.	57292-44-1
Molecular Formula	C₁₄H₁₈ClNO₄
Molecular Weight	299.75 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-4-chlorophenylalanine; Boc-D-4-chloro-Phe-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-(4-chlorophenyl)propanoic acid; Boc-D-p-chlorophenylalanine; D-Boc-4-chlorophenylalanine; N-Boc-D-4-chlorophenylalanine; Boc-D-Phe(4-Cl)-OH; tert-Butyl (R)-(4-chlorophenyl)alaninate N-carboxylate
EINECS	Contact for details

Quality Control

Our Boc-D-4-Chlorophe is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.