Description

Boc-Trp-Obzl CAS NO 57229-67-1 is a protected amino acid derivative, specifically N-tert-butoxycarbonyl-L-tryptophan benzyl ester, serving as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing orthogonal protection for the tryptophan side chain and α-amino group, enabling precise and efficient construction of complex peptide sequences. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, research biochemicals, and novel drug candidates.

Application

• Pharmaceutical Peptide Synthesis: A key raw material for the controlled incorporation of tryptophan residues during the synthesis of therapeutic peptides and peptide-based APIs.
• Research & Development: Used in academic and industrial R&D labs for constructing custom peptide sequences for structure-activity relationship (SAR) studies and biological screening.
• Bioconjugation & Labeling: Serves as a precursor for introducing the indole moiety of tryptophan into larger biomolecules for conjugation or labeling purposes.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening in drug discovery platforms.
• Process Development: Used in scaling up and optimizing peptide manufacturing processes under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	Boc-Trp-Obzl
CAS No.	57229-67-1
Molecular Formula	C25H28N2O4
Molecular Weight	420.50 g/mol
Synonyms	N-α-Boc-L-tryptophan benzyl ester; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoic acid benzyl ester; Boc-L-tryptophan-OBzl; Boc-L-Trp-OBzl; Boc-Trp-OBzl; tert-Butoxycarbonyl-L-tryptophan benzyl ester; BOC-TRP-OBZ; N-tert-Butoxycarbonyl-L-tryptophan benzyl ester
EINECS	Contact for details

Quality Control

Our Boc-Trp-Obzl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, typically meeting standards suitable for advanced research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay (HPLC), chiral purity, and impurity profiles. We support compliance with relevant regulatory frameworks, and specifications can be aligned with customer-specific requirements for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light exposure to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.