Description

2-(Difluoromethoxy)-1-Methoxy-4-Nitrobenzene is a specialized fluorinated aromatic compound, serving as a critical intermediate in advanced organic synthesis. Its unique difluoromethoxy and nitro substituents make it a valuable building block for constructing complex molecules with tailored electronic and physical properties. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental persistence.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and electronic materials that benefit from fluorine's unique properties like thermal stability and low surface energy.
• Organic Synthesis Building Block: Facilitates complex reactions such as nucleophilic aromatic substitution (SNAr) and cross-coupling reactions, enabling the construction of diverse chemical libraries for screening.

Basic Information

Product Name	2-(Difluoromethoxy)-1-Methoxy-4-Nitrobenzene
CAS No.	57213-27-1
Molecular Formula	C8H7F2NO4
Molecular Weight	219.14 g/mol
Synonyms	1-Methoxy-2-(difluoromethoxy)-4-nitrobenzene; 4-Nitro-2-(difluoromethoxy)anisole; Benzene, 2-(difluoromethoxy)-1-methoxy-4-nitro-; 2-(Difluoromethoxy)-4-nitroanisole
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-1-Methoxy-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for research and industrial use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.