Description

3-Methyl-3-(2-Tetrahydropyranyloxy)-1-Propyne is a specialized organic building block featuring both a propargylic ether and a tetrahydropyranyl (THP) protecting group. This unique bifunctional structure makes it a valuable intermediate for the controlled synthesis of complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable intermediates for constructing molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), leveraging the alkyne functionality for click chemistry or Sonogashira coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel crop protection agents and pesticides.
• Fine Chemical Production: Serves as a precursor for synthesizing specialty chemicals, flavors, fragrances, and advanced polymer monomers.
• Academic & Industrial R&D: A versatile reagent in organic synthesis laboratories for methodological studies and the construction of complex natural product analogs.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers and resins with tailored properties.

Basic Information

Product Name	3-Methyl-3-(2-Tetrahydropyranyloxy)-1-Propyne
CAS No.	57188-99-5
Molecular Formula	C9H14O2
Molecular Weight	154.21 g/mol
Synonyms	3-Methyl-3-(tetrahydro-2H-pyran-2-yloxy)-1-propyne; 2-[(2-Methyl-3-butyn-2-yl)oxy]tetrahydro-2H-pyran; 3-Butyn-2-ol, 2-methyl-, 2-tetrahydropyranyl ether; THP ether of 2-Methyl-3-butyn-2-ol; Propargyl THP ether derivative; 2-Methyl-3-butyn-2-yl tetrahydropyran-2-yl ether
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our products undergo comprehensive analytical testing, including GC, HPLC, and NMR, to verify identity and purity against established specifications. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request. Our manufacturing processes adhere to cGMP principles where applicable, supporting our commitment to supply reliability and technical excellence for critical B2B applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index	1.450 - 1.460
Density	0.98 - 1.02 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.