Description

Paxilline CAS NO 57186-25-1 is a potent tremorgenic mycotoxin and a specific, high-affinity blocker of large-conductance calcium-activated potassium (BK) channels. This unique mode of action makes it a critical research tool in neuroscience and electrophysiology for studying ion channel function and neuronal excitability. It is primarily utilized by academic researchers, pharmaceutical R&D teams, and contract research organizations (CROs) focused on neurological disorders, cardiovascular research, and channelopathy studies.

Application

• Neuroscience Research: As a selective BK channel inhibitor for studying synaptic transmission, neuronal firing patterns, and the role of BK channels in neurological function and disease models.
• Electrophysiology Studies: A key pharmacological tool in patch-clamp experiments to characterize BK channel currents and their modulation in various cell types.
• Cardiovascular Research: Investigation of BK channel roles in vascular smooth muscle tone, blood pressure regulation, and cardiac electrophysiology.
• Toxicology & Mycology: Reference standard for the detection and study of tremorgenic mycotoxins produced by Penicillium and Aspergillus species.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify novel BK channel modulators for therapeutic applications.
• Cellular Signaling Pathways: Tool compound for dissecting calcium-signaling cascades and their downstream effects mediated through BK channels.

Basic Information

Product Name	Paxilline
CAS No.	57186-25-1
Molecular Formula	C27H33NO4
Molecular Weight	435.56 g/mol
Synonyms	Paxillin; NSC 341984; (-)-Paxilline; (3b,5a,10b,13a)-3,10,13-Trihydroxy-3,4,5,6,9,10,13,14-octahydro-3,5a,6-trimethyl-1H-5,10b-epoxybenzo[c]indeno[1,2-f]azulen-1-one; Tremorgenic mycotoxin paxilline; BK Channel Blocker Paxilline
EINECS	Contact for details

Quality Control

Our Paxilline is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and safety data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep under inert atmosphere if specified for the specific grade.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.