Description

(Pivaloyloxy)Methyl (6R-Trans)-7-Amino-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride is a key pharmaceutical intermediate, specifically the pivaloyloxymethyl (POM) ester prodrug of the β-lactam antibiotic cefpodoxime. This compound is of critical importance for enhancing the bioavailability and stability of the active pharmaceutical ingredient (API) during formulation and storage. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries engaged in the synthesis of advanced cephalosporin antibiotics.

Application

• Primary Intermediate for Cefpodoxime Proxetil: The essential building block in the commercial synthesis of the broad-spectrum oral cephalosporin antibiotic, cefpodoxime proxetil.
• Pharmaceutical R&D: Used in research laboratories for developing new prodrug formulations and studying structure-activity relationships in β-lactam antibiotics.
• Fine Chemical Synthesis: Serves as a specialized intermediate for synthesizing novel cephalosporin derivatives and analogs in advanced organic chemistry.
• GMP Manufacturing: Supplied to certified facilities for the production of finished dosage forms (tablets, suspensions) under Good Manufacturing Practices.
• Reference Standard: Utilized as a high-purity chemical reference standard for quality control and analytical method development in pharmaceutical analysis.

Basic Information

Product Name	(Pivaloyloxy)Methyl (6R-Trans)-7-Amino-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride
CAS No.	57184-01-7
Molecular Formula	C16H23N3O6S•HCl
Molecular Weight	421.90 g/mol (Free base: 385.43 g/mol)
Synonyms	Cefpodoxime Pivaloyloxymethyl Ester Hydrochloride; Cefpodoxime Proxetil Intermediate; (6R,7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, 1-[[(1,1-Dimethylethoxy)carbonyl]oxy]ethyl Ester Hydrochloride; POM Ester of Cefpodoxime HCl; 1-[[(1,1-Dimethylethoxy)carbonyl]oxy]ethyl (6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetamido]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Hydrochloride
EINECS	Contact for details

Quality Control

Our (Pivaloyloxy)Methyl (6R-Trans)-7-Amino-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride is manufactured under strict quality systems. We provide material suitable for pharmaceutical applications, with quality assurance protocols aligned with ICH guidelines. Certificates of Analysis (COA) documenting identity, purity, and related substances are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.