Description

4-Amino-2-Hydroxy-1,1,1-Trifluorobutane is a versatile fluorinated amino alcohol building block, offering a unique combination of a chiral center, amino functionality, and trifluoromethyl group. This trifluoromethylated compound is highly valued for its ability to impart metabolic stability and modulate lipophilicity in advanced molecular structures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drug candidates, including protease inhibitors and CNS-active molecules.
• Agrochemical Synthesis: Used in creating advanced, fluorinated herbicides and pesticides with enhanced efficacy and environmental profiles.
• Peptide Mimetics: Incorporation into peptide backbones to improve stability against enzymatic degradation.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Material Science Research: Building block for specialty polymers and advanced materials with unique surface properties.
• Fluorine Chemistry Research: A valuable substrate for studying the introduction and reactivity of fluorine-containing groups in organic synthesis.

Basic Information

Product Name	4-Amino-2-Hydroxy-1,1,1-Trifluorobutane
CAS No.	57165-84-1
Molecular Formula	C4H8F3NO
Molecular Weight	143.11 g/mol
Synonyms	2-Hydroxy-4-amino-1,1,1-trifluorobutane; 1,1,1-Trifluoro-2-hydroxy-4-aminobutane; 4-Amino-1,1,1-trifluoro-2-butanol; 4-Amino-2-hydroxy-1,1,1-trifluorobutane; 4-Amino-1,1,1-trifluorobutan-2-ol; (2R/S)-4-Amino-1,1,1-trifluorobutan-2-ol (racemate); 4-Amino-2-trifluoromethyl-2-butanol (incorrect but common); Amino-trifluorobutanol
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Hydroxy-1,1,1-Trifluorobutane is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, enantiomeric excess (if applicable), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details (Racemic or Enantiopure)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.