Description

4-Ethynyl-1H-Pyrazole is a versatile heterocyclic building block featuring both a pyrazole ring and a terminal alkyne functional group. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily utilized by pharmaceutical, agrochemical, and material science industries for constructing novel compounds, including potential active ingredients and functional polymers. Its reactivity allows for efficient coupling and cycloaddition reactions, enabling the rapid exploration of new chemical spaces.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of new drug candidates, particularly for creating kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science & Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and metal-organic frameworks (MOFs).
• Chemical Biology & Bioconjugation: The terminal alkyne enables "click chemistry" (CuAAC) reactions for labeling biomolecules, probe development, and proteomics research.
• Ligand Synthesis in Catalysis: Employed to create novel pyrazole-based ligands for transition metal catalysts used in organic synthesis.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and exploratory chemistry in university and CRO laboratories.

Basic Information

Product Name	4-Ethynyl-1H-Pyrazole
CAS No.	57121-49-0
Molecular Formula	C5H4N2
Molecular Weight	92.10 g/mol
Synonyms	4-Ethynyl-1H-pyrazole; 1H-Pyrazole-4-ethyne; 4-Ethynylpyrazole; 4-Ethynyl-1H-1,2-diazole; 4-Pyrazolylethyne; 57121-49-0; 4-Ethynylpyrazole (9CI); 4-Ethynyl-1H-pyrazole (AldrichCPR)
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.