Description

Bzl-His(Bzl)-Oh is a protected derivative of the amino acid histidine, specifically designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers who require precise control over side-chain reactivity during the construction of complex peptide chains. It is primarily utilized in pharmaceutical R&D, biotechnology, and academic laboratories for the development of novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block where the benzyl (Bzl) protecting groups shield the histidine imidazole side chain and C-terminus from unwanted reactions.
• Pharmaceutical Intermediate: Used in the research and production of peptide-based drugs targeting various diseases, including metabolic disorders and cancers.
• Bioconjugation: Acts as a modified amino acid for creating site-specifically labeled peptides for imaging, diagnostics, or targeted drug delivery systems.
• Biochemical Research: Employed in studying enzyme-substrate interactions, receptor binding, and protein folding where histidine's properties are essential.
• Custom Peptide Service: A fundamental reagent for contract research organizations (CROs) and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Bzl-His(Bzl)-Oh
CAS No.	57101-60-7
Molecular Formula	C14H17N3O2
Molecular Weight	259.30 g/mol
Synonyms	N-α-Benzyl-N-π-benzyl-L-histidine; Nα,Nπ-Dibenzyl-L-histidine; L-Histidine, N,N'-dibenzyl-; Bzl-His(Bzl)-OH; Dibenzylhistidine; (S)-2-Amino-3-(1-(benzyl)-1H-imidazol-4-yl)propanoic acid; Nα-Benzyl-N-im-benzylhistidine; Fmoc-His(Bzl)-OH precursor
EINECS	Contact for details

Quality Control

Our Bzl-His(Bzl)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry guidelines for fine chemical and pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.