Description

Para-Hydroxyclonidine is a key chemical intermediate and reference standard of significant interest in pharmaceutical research and development. Its primary value lies in its structural relationship to clonidine, making it a crucial building block for synthesizing novel analogs and for use in analytical method development. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who are engaged in the development of central nervous system (CNS) active agents, analytical validation, and process chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of clonidine derivatives and other imidazoline receptor ligands.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing.
• Biochemical Research: Employed in pharmacological studies to investigate the structure-activity relationships (SAR) of α-2 adrenergic and imidazoline receptor agonists.
• Process Development: Serves as a starting material or intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs).
• Metabolite Studies: Utilized in the identification and quantification of metabolic pathways for related pharmaceutical compounds.

Basic Information

Product Name	Para-Hydroxyclonidine
CAS No.	57101-48-1
Molecular Formula	C9H9Cl2N3O
Molecular Weight	246.09 g/mol
Synonyms	4-Hydroxyclonidine; 2-[(2,6-Dichloro-4-hydroxyphenyl)imino]imidazolidine; 2-[(2,6-Dichloro-4-hydroxyphenyl)amino]-2-imidazoline; 4-Hydroxy-2,6-dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzenamine; 2-(2,6-Dichloro-4-hydroxyanilino)-2-imidazoline; Para-Hydroxy Clonidine; 4-Hydroxyclonidine HCl (for salt forms)
EINECS	Contact for details

Quality Control

Our Para-Hydroxyclonidine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.