Description

Boc-N'-(2-Chloro-Cbz)-D-Lysine is a protected derivative of the non-proteinogenic amino acid D-Lysine, featuring orthogonal Boc and 2-chloro-Cbz protecting groups on its side chain. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and side-chain reactivity. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry, particularly for developing novel therapeutic agents and peptide-based drugs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of peptide-based pharmaceuticals and active pharmaceutical ingredients (APIs).
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative for the controlled, sequential assembly of custom peptides with D-configuration lysine residues.
• Medicinal Chemistry & Drug Discovery: Enables the exploration of structure-activity relationships (SAR) by incorporating modified lysine analogs into lead compounds.
• Bioconjugation & Linker Chemistry: The reactive 2-chloro-Cbz protecting group can be utilized for selective deprotection or further functionalization in constructing complex molecular architectures.
• Academic & Industrial Research: A valuable reagent for synthetic organic chemists in universities and R&D departments studying peptide synthesis methodologies.

Basic Information

Product Name	Boc-N'-(2-Chloro-Cbz)-D-Lysine
CAS No.	57096-11-4
Molecular Formula	C20H29ClN2O6
Molecular Weight	428.91 g/mol
Synonyms	Nε-(2-Chlorobenzyloxycarbonyl)-Nα-(tert-butoxycarbonyl)-D-lysine; (2R)-6-[[(2-Chlorophenyl)methoxy]carbonylamino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid; Boc-D-Lys(2-Cl-Z)-OH; N-α-Boc-N-ε-(2-chloro-Cbz)-D-lysine; tert-Butyl N-[(1R)-5-[[(2-chlorophenyl)methoxy]carbonylamino]-1-carboxypentyl]carbamate; D-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-[[(2-chlorophenyl)methoxy]carbonyl]-
EINECS	Contact for details

Quality Control

Our Boc-N'-(2-Chloro-Cbz)-D-Lysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.