Description

1H-Imidazole-4-Carbonitrile is a versatile heterocyclic nitrile building block, essential for advanced organic synthesis and pharmaceutical research. Its unique structure, featuring both an imidazole ring and a cyano group, makes it a critical intermediate for constructing complex molecules with tailored biological activity. This high-purity compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition and other enzyme-related pathways.
• Agrochemical Synthesis: Used in the development of novel fungicides, herbicides, and plant growth regulators due to its bioactive heterocyclic core.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands in coordination chemistry and catalysts for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, conductive polymers, and advanced organic frameworks (MOFs/COFs).
• Bioconjugation and Probe Chemistry: The reactive cyano group allows for further transformation into amides, tetrazoles, and other functional groups used in bioconjugation and diagnostic probe development.

Basic Information

Product Name	1H-Imidazole-4-Carbonitrile
CAS No.	57090-88-7
Molecular Formula	C4H3N3
Molecular Weight	93.09 g/mol
Synonyms	4-Cyanoimidazole; 4-Imidazolecarbonitrile; 1H-Imidazole-4-carbonitrile; Imidazole-4-carbonitrile; 4-CN-Imidazole; 4-Cyanomidazole; 4-Cyano-1H-imidazole
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch, and custom specifications to meet cGMP, ICH Q7, or other regulatory guidelines can be discussed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.