Description

(7R)-3-[(1-Methyl-1H-Tetrazol-5-Ylthio)Methyl]-7-[[[[n-[(Guanidino)Carbonyl]-L-Phenylalanyl]Amino]Phenylacetyl]Amino]Cepham-3-Ene-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate belonging to the cephem class of β-lactam antibiotics. This compound is critical for the synthesis of next-generation cephalosporin antibiotics, offering a sophisticated chemical backbone for developing potent antimicrobial agents. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and API producers focused on combating resistant bacterial infections.

Application

• Key Intermediate for Advanced Cephalosporin Synthesis: Serves as a crucial building block in the multi-step synthesis of novel, broad-spectrum cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry programs to develop new antibiotic candidates with improved efficacy against drug-resistant bacteria.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the final stages or penultimate steps of GMP-compliant API production for finished dosage forms.
• Biochemical Research: Utilized in studies investigating the structure-activity relationships (SAR) of β-lactam antibiotics and mechanisms of bacterial resistance.
• Fine Chemical Synthesis: Acts as a specialized substrate for further chemical modifications to create analogs with tailored pharmacokinetic properties.

Basic Information

Item	Details
Product Name	(7R)-3-[(1-Methyl-1H-Tetrazol-5-Ylthio)Methyl]-7-[[[[n-[(Guanidino)Carbonyl]-L-Phenylalanyl]Amino]Phenylacetyl]Amino]Cepham-3-Ene-4-Carboxylic Acid
CAS No.	56779-66-9
Molecular Formula	C33H36N12O6S2
Molecular Weight	736.85 g/mol
Synonyms	7β-[[(Phenylacetyl)glycyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefamandole Intermediate; Cephamandole Precursor; (6R,7R)-7-[[2-[[(Aminocarbonyl)amino]-1-oxo-3-phenylpropyl]amino]phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; L-Phenylalanine, N-[(aminocarbonyl)-, N'-[2-[[(6R,7R)-2-carboxy-8-oxo-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]amino]-1-oxo-2-phenylethyl]amino]-2-oxoethyl]-; Mandol Intermediate
EINECS	Contact for details

Quality Control

Our production of this cephem intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical testing including HPLC for purity and related substances, NMR for structural confirmation, and Karl Fischer titration for water content. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support development and commercial projects requiring standards aligned with ICH guidelines and current Good Manufacturing Practice (cGMP) principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.