Description

Cbz-L-Arginine Hydrochloride is a protected derivative of the essential amino acid L-Arginine, widely used as a key building block in peptide synthesis. Its primary value lies in providing a stable, orthogonal protecting group strategy, enabling the selective construction of complex peptides and proteins. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled, sequential addition of arginine residues in automated and manual peptide synthesis.
• Solution-Phase Peptide Synthesis: Used in classical solution methods for constructing peptide fragments and small peptides.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation & Protein Engineering: Employed to introduce arginine moieties into larger biomolecules for modifying function, stability, or solubility.
• Biochemical Research: Used in studies of enzyme substrates, receptor ligands, and other biologically active compounds where a protected arginine is required.
• Custom Peptide Service Providers: A staple chemical for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Cbz-L-Arginine Hydrochloride
CAS No.	56672-63-0
Molecular Formula	C14H21N5O4 • HCl
Molecular Weight	359.81 g/mol
Synonyms	Nα-Carbobenzoxy-L-arginine hydrochloride; Z-Arg-OH • HCl; Nα-Cbz-L-arginine hydrochloride; Benzyloxycarbonyl-L-arginine hydrochloride; (S)-2-(((Benzyloxy)carbonyl)amino)-5-guanidinopentanoic acid hydrochloride; L-Arginine, N2-[(phenylmethoxy)carbonyl]-, hydrochloride (1:1); CBZ-L-ARGININE HCL
EINECS	Contact for details

Quality Control

Our Cbz-L-Arginine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with research and cGMP-grade requirements for advanced synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	+10.0° to +12.0° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.