Description

Cathepsin G is a serine protease enzyme belonging to the chymotrypsin family, primarily stored in the azurophil granules of neutrophils. This product, identified by CAS NO 56645-49-9, is a critical reagent for studying proteolytic activity and inflammatory pathways in biological research. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors who require high-purity enzymes for biochemical assays, drug discovery, and the study of immune response mechanisms.

Application

• Biochemical Research: Used as a model serine protease to study enzyme kinetics, substrate specificity, and inhibitor interactions.
• Pharmaceutical Development: Employed in screening assays to identify and characterize novel protease inhibitors for therapeutic applications.
• Immunology Studies: Critical for investigating the role of neutrophil-derived proteases in inflammation, tissue remodeling, and host defense.
• Proteomics: Utilized for the controlled digestion of proteins in sample preparation for mass spectrometry analysis.
• Diagnostic Reagent Manufacturing: Serves as a key component in the development of enzymatic diagnostic kits and calibration standards.
• Cell Biology: Applied in studies of apoptosis, extracellular matrix degradation, and cell signaling pathways mediated by proteolytic cleavage.

Basic Information

Product Name	Cathepsin G
CAS No.	56645-49-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cathepsin G (Human Leukocyte); Cathepsin G (Human Neutrophil); CTSG; CG; Serine protease Cathepsin G; Azurophil Granule Protein; Leukocyte Cathepsin G; Neutrophil Cathepsin G; EC 3.4.21.20
EINECS	Contact for details

Quality Control

Our Cathepsin G is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analysis, including assessment of purity, specific activity, and absence of contaminating proteases. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For optimal performance, aliquot the product upon receipt to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Activity)	Conforms
Specific Activity	≥ 50 units/mg protein
Purity (SDS-PAGE)	≥ 90%
Protein Content (Biuret)	Contact for details
Solubility	Soluble in water or appropriate buffer
Endotoxin Level (LAL)	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.