Description

Glutaryl-7-Aminocephalosporanicacidacylase CAS NO 56645-46-6 is a specialized enzyme crucial for the semi-synthetic production of advanced cephalosporin antibiotics. This biocatalyst enables the selective deacylation of glutaryl side chains, a key step in creating high-purity, potent antibiotic intermediates. It is an essential component for pharmaceutical manufacturers and research institutions focused on developing and scaling up next-generation β-lactam antibiotics to meet global healthcare demands.

Application

• Key Intermediate Synthesis: Enzymatic production of 7-Aminocephalosporanic acid (7-ACA) and its derivatives from cephalosporin C.
• Pharmaceutical Manufacturing: Critical biocatalyst in the industrial-scale synthesis of semi-synthetic cephalosporin antibiotics such as cefazolin, cephalothin, and cephradine.
• Biocatalytic Process Development: Used in R&D for optimizing enzymatic conversion routes to improve yield, purity, and cost-efficiency in antibiotic production.
• Enzyme Immobilization Studies: A model enzyme for research into immobilized enzyme systems to enhance operational stability and reusability in continuous flow reactors.
• Biochemical Research: Tool for studying enzyme kinetics, specificity, and protein engineering to develop novel acylase variants with improved properties.

Basic Information

Product Name	Glutaryl-7-Aminocephalosporanicacidacylase
CAS No.	56645-46-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Glutaryl-7-ACA Acylase; Glutaryl Acylase; Cephalosporin C Acylase; Glutaryl-7-Aminocephalosporanic Acid Acylase; GCA; GL-7-ACA Acylase; EC 3.5.1.93; Glutaryl-7-β-(4-Carboxybutanamido)cephalosporanic Acid Acylase
EINECS	Contact for details

Quality Control

Our Glutaryl-7-Aminocephalosporanicacidacylase is produced and tested under a strict quality management system. Each batch is characterized for key enzymatic parameters including specific activity, protein content, and purity to ensure consistent performance in your biocatalytic processes. Certificates of Analysis (COA) detailing assay results, stability data, and microbiological limits are provided and available upon request to support your regulatory and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This material is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a cool, dry environment to maintain enzymatic activity and stability. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (IR)	Conforms
Protein Content (Biuret)	> 90%
Specific Activity (U/mg)	Contact for details
Purity (SDS-PAGE)	Single major band
pH (in solution)	6.5 - 7.5
Solubility	Soluble in buffer or water
Microbial Limits	Meets standard bioburden requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.