Description

3-Dimethylaminopropyllithium is a highly reactive organolithium compound widely used as a powerful nucleophile and base in advanced organic synthesis. Its value lies in its ability to efficiently introduce the 3-dimethylaminopropyl functional group, a key building block for pharmaceuticals and specialty chemicals. This reagent is essential for research and production chemists in the pharmaceutical, agrochemical, and materials science industries seeking to create complex nitrogen-containing molecules.

Application

• As a key reagent for the synthesis of pharmaceutical intermediates, particularly those containing tertiary amine functionalities.
• In the preparation of ligands for catalysis and organometallic complexes used in polymerization and cross-coupling reactions.
• For the alkylation of various electrophiles, including carbonyl compounds, epoxides, and halides, in fine chemical production.
• As a strong base for deprotonation reactions in the synthesis of specialty polymers and advanced materials.
• In the development of active pharmaceutical ingredients (APIs) for central nervous system (CNS) and other therapeutic agents.
• For the functionalization of surfaces and nanoparticles in materials science research.

Basic Information

Product Name	3-Dimethylaminopropyllithium
CAS No.	56633-21-7
Molecular Formula	C5H12LiN
Molecular Weight	93.10 g/mol
Synonyms	Lithium (3-dimethylaminopropyl); (3-Dimethylaminopropyl)lithium; N,N-Dimethyl-3-aminopropyllithium; 3-(Dimethylamino)propyllithium; 1-Lithio-3-dimethylaminopropane; DMAPLi; 3-Dimethylaminopropyl lithium reagent
EINECS	Contact for details

Quality Control

Our 3-Dimethylaminopropyllithium is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including titration for active lithium content and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for purity, concentration, and suitability for your process.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for extended stability. This material is highly volatile, easily oxidized, and reacts violently with moisture and air; it must be handled exclusively under an inert atmosphere using appropriate Schlenk or glovebox techniques.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms
Concentration (Titration)	Typically 0.5 M - 2.0 M in specified solvent*
Assay (Active RLi)	≥ 95%
Solvent	Cyclohexane, Diethyl ether, or THF
Impurities (GC/HPLC)	Meets internal specifications

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.