Description

Isopropyllithium is a highly reactive organolithium compound, widely recognized for its powerful nucleophilic and basic properties. It serves as a critical reagent in organic synthesis, enabling the efficient formation of carbon-carbon bonds. This compound is essential for research and production in the pharmaceutical, agrochemical, and advanced materials sectors, where precise and controlled alkylation reactions are required.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the alkylation of carbonyl compounds and other electrophiles in the production of active pharmaceutical ingredients (APIs).
• Polymer Chemistry: Used as an initiator in anionic polymerization processes to create specialized polymers and elastomers with controlled architectures.
• Fine Chemical Manufacturing: Employed in the synthesis of complex organic molecules, including flavors, fragrances, and specialty chemicals.
• Agrochemical Research: Facilitates the construction of novel molecular scaffolds for the development of new herbicides and pesticides.
• Material Science: Applied in the surface modification of inorganic materials and the synthesis of organometallic precursors.
• Lithiation Reactions: Effective for directed ortho-metalation (DoM) and other deprotonation strategies to functionalize aromatic systems.

Basic Information

Product Name	Isopropyllithium
CAS No.	1888-75-1
Molecular Formula	C3H7Li
Molecular Weight	50.00 g/mol
Synonyms	2-Propyllithium; Lithium isopropyl; Isopropyl lithium; Lithium isopropanide; (Propan-2-yl)lithium; i-PrLi; i-Propyl-Li; Lithium(1+) propan-2-ide
EINECS	217-548-8

Quality Control

Our Isopropyllithium is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Production adheres to cGMP principles where applicable. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, concentration (typically in solution), and impurity profiles. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a highly volatile and easily oxidized strong base, it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. Handle and store away from moisture, air, and incompatible materials in a cool, dry, and well-ventilated area dedicated to pyrophoric reagents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to slightly yellow liquid
Assay (Titration)	0.5 M - 2.0 M in specified solvent (e.g., cyclohexane, heptane)
Purity (NMR)	≥ 95%
Identification (IR)	Conforms to structure
Water Content (KF)	≤ 0.1%
Acidity (Titration)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.