Description

(2-Pyridylmethyl)Lithium is a highly reactive organolithium reagent, specifically a pyridine-functionalized alkyl lithium compound. This specialized reagent is valued for its ability to introduce the 2-pyridylmethyl moiety into target molecules, enabling the synthesis of complex nitrogen-containing heterocycles and ligands. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing key molecular scaffolds.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating active pharmaceutical ingredients (APIs) and novel drug candidates, particularly those containing pyridine or bipyridine structures.
• Ligand Preparation for Catalysis: Used in the synthesis of sophisticated nitrogen-donor ligands for transition metal catalysts used in asymmetric synthesis and polymerization.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides where the pyridylmethyl group imparts specific biological activity.
• Material Science & Functional Polymers: Serves as a monomer or initiator in the development of specialty polymers with tailored electronic or coordination properties.
• Organic Synthesis & Methodology Development: A versatile reagent for nucleophilic addition and metal-halogen exchange reactions in academic and industrial R&D laboratories.

Basic Information

Product Name	(2-Pyridylmethyl)Lithium
CAS No.	1749-29-7
Molecular Formula	C6H6LiN
Molecular Weight	99.07 g/mol
Synonyms	2-(Lithiomethyl)pyridine; Lithium(2-pyridyl)methanide; 2-Pyridylmethyllithium; (Pyridin-2-ylmethyl)lithium; 2-Picolyl lithium; α-Lithio-2-picoline
EINECS	Contact for details

Quality Control

Our (2-Pyridylmethyl)Lithium is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, concentration (typically supplied in a specified solvent like diethyl ether or THF), and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive and hygroscopic (moisture-sensitive) nature, this reagent must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. The storage area should be cool, dry, and well-ventilated, away from incompatible materials such as moisture, acids, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Colorless to pale yellow solution
Assay (Titration)	0.5 M in solvent (e.g., diethyl ether/THF), or as specified
Purity (NMR)	≥ 95% (relative)
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.