Description

n-Butyllithium is a highly reactive organolithium compound, widely recognized as a powerful base and nucleophile in synthetic organic chemistry. Its primary value lies in its ability to perform efficient deprotonation and lithium-halogen exchange reactions, making it indispensable for constructing complex carbon frameworks. This reagent is essential for industries and research facilities involved in pharmaceuticals, agrochemicals, advanced polymers, and specialty chemical synthesis.

Application

• As a strong base for the deprotonation of weak carbon acids in the synthesis of pharmaceuticals and fine chemicals.
• As a key reagent in anionic polymerization initiator systems for producing synthetic rubbers like polybutadiene and styrene-butadiene rubber (SBR).
• For lithium-halogen exchange reactions to generate functionalized organolithium intermediates.
• In the synthesis of lithium enolates for aldol and related condensation reactions.
• As a catalyst or initiator in the production of specialty polymers and elastomers.
• In metallation reactions for the functionalization of aromatic and heteroaromatic compounds.
• For the preparation of other organometallic reagents used in cross-coupling reactions.
• In research and development for exploring new synthetic methodologies and pathways.

Basic Information

Product Name	n-Butyllithium
CAS No.	109-72-8
Molecular Formula	C4H9Li
Molecular Weight	64.06 g/mol
Synonyms	Butyllithium; n-BuLi; 1-Lithiobutane; Lithium butyl; Butyl lithium; Lithium butanide; NSC 51139
EINECS	203-698-8

Quality Control

Our n-Butyllithium is manufactured under stringent controls to ensure batch-to-batch consistency and high reactivity. Quality is verified through rigorous analytical testing, including titration for precise assay determination and analysis of key impurities. A Certificate of Analysis (COA) detailing purity, concentration, and solvent content is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a highly volatile and easily oxidized (store under inert atmosphere) pyrophoric material, it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, well-ventilated area, away from heat, sparks, and open flames. Specific storage temperature recommendations depend on the solvent concentration and are provided on the material safety data sheet (MSDS).

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Assay (by Titration)	Typically 1.6M, 2.0M, or 2.5M in hexanes or other specified solvents
Purity (n-BuLi)	≥ 95% (by NMR or GC)
Acidity (as n-BuOH)	≤ 1%
Solvent Content	As specified (e.g., Hexanes, Cyclohexane)
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.