Description

5-Methylnicotinamide-Adenine Dinucleotide is a specialized coenzyme analog, a methylated derivative of the essential redox cofactor NAD+. This compound is of significant value in biochemical research and development, particularly for studying enzyme mechanisms and cellular metabolism where the standard nicotinamide moiety is modified. It serves as a critical reagent for researchers and manufacturers in the pharmaceutical and life science sectors, enabling advanced studies in enzymology, metabolic pathway analysis, and drug discovery.

Application

• Enzymology Research: Used as a substrate or inhibitor to probe the specificity and catalytic mechanisms of NAD+-dependent dehydrogenases and other enzymes.
• Metabolic Studies: Employed in investigating altered metabolic pathways, especially those involving methyl group transfer and redox reactions in cellular models.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the synthesis and testing of novel therapeutics targeting metabolic diseases or enzyme dysfunction.
• Diagnostic Reagent Manufacturing: Utilized in the formulation of specialized diagnostic kits and assays for clinical and research laboratories.
• Biochemical Synthesis: Acts as a cofactor in enzymatic synthesis processes for producing fine chemicals or chiral compounds.
• Academic & Institutional Research: A vital tool for universities and research institutes conducting fundamental studies in biochemistry and molecular biology.

Basic Information

Product Name	5-Methylnicotinamide-Adenine Dinucleotide
CAS No.	56541-76-5
Molecular Formula	C22H28N7O14P2
Molecular Weight	700.45 g/mol
Synonyms	5-Methyl-NAD; 5-Methylnicotinamide Adenine Dinucleotide; 5-Methyl-NAD+; 5-Me-NAD; 3-Carbamoyl-1-(5-O-{hydroxy[hydroxy({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphoryl]phosphoryl}oxy-1,4-anhydro-D-ribitol-3-yl)pyridin-1-ium-5-carboxylate; Methylated NAD analog; NAD derivative with 5-methylnicotinamide
EINECS	Contact for details

Quality Control

Our 5-Methylnicotinamide-Adenine Dinucleotide is produced and tested under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); containers should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For extended storage under inert atmosphere, seal under argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by enzymatic or spectrophotometric method)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.