Description

1-[4-(Trifluoromethoxy)Phenyl]Butan-1-One is a high-value fluorinated aromatic ketone building block. This compound is significant for its trifluoromethoxy (-OCF₃) substituent, a privileged structural motif known to enhance metabolic stability, lipophilicity, and bioavailability in active molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas like central nervous system (CNS) drugs, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve pesticidal activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated structure.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and activity-based protein profiling (ABPP) agents to study enzyme function.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-[4-(Trifluoromethoxy)Phenyl]Butan-1-One
CAS No.	56465-82-8
Molecular Formula	C₁₁H₁₁F₃O₂
Molecular Weight	232.20 g/mol
Synonyms	4'-Trifluoromethoxybutyrophenone; 1-[4-(Trifluoromethoxy)phenyl]-1-butanone; 4-(Trifluoromethoxy)butyrophenone; Butan-1-one, 1-[4-(trifluoromethoxy)phenyl]-; p-Trifluoromethoxybutyrophenone; 4-Trifluoromethoxybutyrophenone; 1-(4-Trifluoromethoxyphenyl)butan-1-one
EINECS	Contact for details

Quality Control

Our production of 1-[4-(Trifluoromethoxy)Phenyl]Butan-1-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP (current Good Manufacturing Practice) standards for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.