Description

α-Hydroxymetoprolol is a key pharmaceutical intermediate and metabolite of the widely used β-blocker, Metoprolol. This compound is essential for research and development in the synthesis of new cardiovascular drugs and for conducting detailed pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories focused on drug development and quality control.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and process development of Metoprolol and its related analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods for drug metabolism and pharmacokinetic (DMPK) studies.
• Impurity Standard: Serves as a certified reference material for identifying and quantifying related substances in Metoprolol Active Pharmaceutical Ingredient (API) and finished dosage forms.
• Research Chemical: Employed in academic and industrial research to investigate the structure-activity relationships (SAR) of β-adrenergic blocking agents.
• Quality Control: Essential for HPLC and LC-MS method development and validation within pharmaceutical quality assurance laboratories.

Basic Information

Product Name	α-Hydroxymetoprolol
CAS No.	56392-16-6
Molecular Formula	C15H25NO4
Molecular Weight	283.36 g/mol
Synonyms	1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol, α-Hydroxymetoprolol; O-Desmethylmetoprolol; Metoprolol Metabolite; H 119/66; H11966
EINECS	Contact for details

Quality Control

Our α-Hydroxymetoprolol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.