Description

5,7,8-Trimethyltocol Trifluoroacetate is a chemically modified derivative of tocol, a key member of the vitamin E family, designed for enhanced stability and analytical utility. This compound is of significant value as a high-purity reference standard and a crucial synthetic intermediate in the research and development of pharmaceuticals and nutraceuticals. It is primarily required by manufacturers and R&D laboratories in the pharmaceutical, analytical chemistry, and life science sectors for precise quantification, method validation, and advanced synthesis.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the accurate identification and quantification of vitamin E analogs and metabolites in drug formulations and biological samples via HPLC and LC-MS.
• Analytical Chemistry: Serves as a critical calibration standard in method development and validation for quality control laboratories to ensure assay accuracy and compliance with pharmacopeial monographs (e.g., USP, EP).
• Nutraceutical & Cosmetic R&D: Employed as a key intermediate in the synthesis of novel, stabilized vitamin E derivatives for enhanced antioxidant efficacy in dietary supplements and topical skincare products.
• Biochemical Research: Utilized in metabolic studies to investigate the absorption, distribution, and biological activity of tocopherols and tocotrienols in model systems.
• Chemical Synthesis: Acts as a protected or activated intermediate for the preparation of more complex molecules in medicinal chemistry and organic synthesis.

Basic Information

Product Name	5,7,8-Trimethyltocol Trifluoroacetate
CAS No.	56272-54-9
Molecular Formula	C33H53O3F3
Molecular Weight	554.78 g/mol
Synonyms	d-δ-Tocopherol Trifluoroacetate; (2R)-2,5,8-Trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl Trifluoroacetate; δ-Tocopherol TFA; δ-Tocopherol Trifluoroacetate; 5,7,8-Trimethyltocol TFA Ester; Vitamin E δ-Homolog Trifluoroacetate; Tocol, 5,7,8-trimethyl-, trifluoroacetate
EINECS	Contact for details

Quality Control

Every batch of 5,7,8-Trimethyltocol Trifluoroacetate is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic purity analysis, to ensure compliance with high-purity reference standard requirements. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its light-sensitive and easily oxidized nature, prolonged exposure to light, air, or elevated temperatures should be avoided to maintain stability and purity. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (e.g., methanol, acetonitrile, chloroform)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.